We are happy to inform that our paper “The impact of HPV infection on human glycogen and lipid metabolism – a review” has been published in Biochimica et Biophysica Acta (BBA) – Reviews on Cancer (IF=10.68 and 200 ministerial points).
The human papillomavirus (HPV) is the most important cause of cervical cancer – 99% of cervical cancer patients are infected with HPV. This close link between HPV and cancer raises the question of whether and how HPV affects cells to reprogram their metabolism? The published article tries to answer this question. Focusing on the early phase proteins E1, E2, E5, E6 and E7, we showed that HPV activates many metabolic pathways and directly affects the enzymes of the glycolysis pathway, promoting the Warburg effect by increasing glucose uptake, activating glycolysis and the pentose-phosphate pathway, increasing the level of lactate dehydrogenase A synthesis and inhibition of β-oxidation. The conducted analysis leads to the conclusion that HPV is significantly involved in the metabolic reprogramming of cells towards the neoplastic phenotype, and its metabolic activity is the main cause of its oncogenicity.
Due to the high importance of the topic and interdisciplinary work with cooperation with dr hab. Sława Szostek from the Department of Molecular Medical Microbiology, Department of Microbiology, Faculty of Medicine CMUJ, the work was published on the main website of the Jagiellonian University (here)
The paper is available here.